DRASTIC will pave the way for significant whole life-cycle GHG emission reduction in new construction and (deep-energy) retrofit by demonstrating affordable innovative circular solutions in 5 different geographical zones, covering different building layers (accounting for 90% of GHG emissions), raw materials (accounting for 72% GHG emissions), buildings typologies (accounting for 80% of all buildings), circular strategies (reaching up to 60% of GHG emission reduction), and local drivers. The demonstrators untap on EU scale the potential of 491 MTCO2-eq savings annually and a financial divergence potential of 33.4 B€ annually, within defined market conditions and based on circular business models. To reach this ambitious goal, 23 partners from 8 European countries collaborate, covering the entire value chain and supported by a co-creation strategy with relevant stakeholders. To assess and validate the solutions, an innovative multi-cyclic performance assessment framework will be developed and applied, integrating multi-cycle LCA, multi-cycle LCC, circularity and sufficiency for construction and building related products and components. Novel data-driven tools covering quality evaluation, thermal efficiency, automatic identification of assets and their reusability condition, multi-cycle traceability, and social acceptance will be enhanced, demonstrated and combined in a toolbox integrated in a common digital platform, going beyond a digital building logbook. High impact dissemination and communication of results/key deliverables will be led by the World Green Building Council and maximized by its global network. The DRASTIC project will contribute to the objectives of the EU by demonstrating the feasibility of promising and affordable new technologies, processes and products combined with new business models for faster market uptake, leading towards more sustainable buildings with reduced life-cycle carbon, high life-cycle performance and reduced life-cycle costs.