MESMERISE will develop and test a High-resolution non-intrusive scanner up to TRL 5 able to automatically detect and identify both internal and external concealed commodities being entirely independent of human operator interpretation and training and based on two complementary technologies: ultra-low-dose Multispectral Xray transmission and Infrasonic interrogation. A novel x-ray detector, in addition to a higher imaging resolution, captures 256 channels of spectroscopic information, allowing a step change in material identification. Crucially, this level of resolution has the potential to enhance the detection of narcotics and explosives concealed in the body -a highly complex problem with currently available equipment. A second subsystem for detecting externally concealed items based on a novel, intrinsically safe, technology (infrasound near-field acoustic holography) is entirely new to security screening. Low-fq MEM Micro-technology shall also be exploited to provide an automated version of non-contact pat-down. Both sub-systems will be able to work independently, or together to provide complementary information and improve the detection of externally concealed objects. Automated algorithms for both subsystems and, through data fusion techniques, for the combined system will identify chemical substances, recognise pattern and detect anomalies with100g threshold in any part of the body, including prosthetic elements or plasters. A big manufacturer of body scanners, SMEs, Univs, R&D centres, end-users and a diverse and high quality external advisory board, with a broad international contribution and connection to US counterparts provides a straightforward exploitation route. Acceptance by society will be promoted by communication activities highlighting its non-contact nature, non divest condition and the absence of the requirement for operators to view explicit images through automated detection making MESMERISE intrinsically respectful of dignity and privacy.