Project FISHY aims at designing, developing, validating and demonstrating a coordinated framework for cyber resilience provisioning to guarantee a trusted supply chain of ICT systems, built upon distributed, dynamic, and often fundamentally insecure and heterogeneous ICT infrastructures. We propose to design a novel FISHY platform able to securely orchestrate a supply chain consisting of complex ICT systems end-to-end, - from the IoT ecosystem and the edge and cloud infrastructure over to the networking infrastructure connecting -, and enabling functionalities related to risks and vulnerabilities management, accountability and mitigation strategies as well as security metrics and evidence-based security assurance. Conceptually, FISHY platform uses intent-based interfaces to orchestrate both existing and beyond state-of-the-art security appliances in composed ICT scenarios leveraging capabilities of programmable network and IT infrastructure through a coordinated management. FISHY implements new strategies to leveraging data analytics, distributed ledger technology, intent-based security service orchestration, artificial intelligence and programmable network infrastructure. The platform is envisioned not only to facilitating adaptive system reconfigurations, but also reacting to and defying the effects of cyber attacks in real time of the ICT supply chain end-to-end, and in particular in the IoT domain. Finally, the FISHY proposes a comprehensive validation and demonstration strategy built upon three use cases from different sectors, including agriculture, manufacturing and transportation. The expected project outcome is a Proof-of-Concept (PoC) of the FISHY platform, along with the dissemination and ambitious exploitation strategies.