The timely recognition of a cardiopulmonary deterioration in hospitalized patients can allow the prevention of potentially fatal complications, such as a state of shock and a cardiac arrest. Nurses’ clinical judgment, which refer to their interpretation of patients’ clinical state, is essential to recognize a cardiopulmonary deterioration, to limit the intensity of care needed to respond to it and to avoid the occurrence of complications. However, a lack of knowledge about cardiopulmonary deterioration signs and a lack of confidence of nurses in their clinical judgment undermine the early recognition of cardiopulmonary deterioration signs. Serious games (SGs; learning games) are electronic learning tools with the potential to enhance users’ competencies. SGs combine experiential learning (through its virtual simulation dimension), with problem-solving learning (through its gaming elements, such as taking on a challenge or solving a problematic situation).To innovate, the project “COEURious G@me”, proposed as part of the “ERASMUS+ : Strategic Partnerships” call for proposals, mobilizes the contributions of four partnered European universities (France, Spain, Belgium), including the expertise and the experience of a Canadian university, to develop and deploy a serious game for nurses and focused on the cardiopulmonary evaluation of patients. This project is part of the continuing education of nurses to enhance their practices and develop their competencies. The proposed project is highly federative, as it combines the contribution from academic faculty members and collaborators in four countries, clinical experts, target users (i.e., nurses), as well as software developers.The objectives of the project are as follow:1.To develop a prototype in French of the serious game “COEURious G@me” and its user’s guide, based on a transnational catalog of nursing competencies to be validated regarding the cardiopulmonary evaluation of patients (first year);2.To propose COEURious G@me, a multilingual serious game (English, Spanish, Dutch) and its user guide (second year);3.To deploy “COEURious G@me” to 1200 nurses working in the health institutions affiliated to the five universities collaborating to this project in France, Spain, Belgium, and Canada: Aix-Marseille Université, the Universidad Pública de Navarra, the Université Libre de Bruxelles, the Erasmus Hogeschool Brussel, and the Université de Montréal (first to third year);4.To disseminate the results of the project through publications and during national and international events.This project aims at supporting the adoption of innovative approaches as well as the adoption of digital and educational technologies with practicing nurses, at developing partnership that support the creation and the implementation of internationalization strategies between universities and professional and continuing training institutions, and at supporting nurses and the members of the team project in the acquisition and development of clinical and digital competencies.A steering committee, composed of project representatives for each partner, will meet during five transnational meetings (four in Europe and one in Canada) planned during the project, and by videoconference each trimester. This committee will ensure the smooth running of the project activities, the meeting of the projected deadlines, and that necessary adjustments to the project are made depending on the specific context all partners. Various quality and performance indicators have been identified and will be monitored, such as nurses’ satisfaction and acceptability of the serious game the level of nurses’ knowledge and confidence regarding the recognition of cardiopulmonary deterioration signs.The project will be completed with the dissemination of results through publications in professional and scientific journals, and at national and international events. An international colloquium will be organized at the end of the project, with online broadcast among all partners, to present the result of the “COEURious G@me” project.