Deciphering the functions of SMARCB1 and BRD9 in the BAF complex mediated chromatin remodeling
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Gene expression drives essential cellular processes in multicellular organisms. The BAF chromatin remodeling complexes are a cluster of proteins that control gene expression in our genome. Mutations in BAF cause many diseases including >20% of human cancer cases. Here, we aim to deconstruct gene regulatory process of two important BAF subunits called SMARCB1 and BRD9. The two subunits are often mutated or amplified in human cancers and neurodevelopmental diseases. Deep understanding the regulatory functions of the two subunits will shed light on pathogenic roles of the mutations in these diseases.
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