In the Netherlands, there is no national approach for early detection of cardiovascular disease, kidney disease and type 2 diabetes in the general population, despite the social and economic impact of these disorders. The Check@Home consortium was founded to fill this gap and is committed to set up an accessible and (cost-)effective national program for the early detection and treatment of chronic diseases to prevent progression and complications. A program that is accessible to all socio-economic groups, takes place in the citizens own living environment, reduces the burden on primary care and contributes to the affordability and sustainability of healthcare. Check@Home is an initiative of the Dutch CardioVascular Alliance, Dutch Heart Foundation, Dutch Kidney Foundation and Dutch Diabetes Research Foundation and involves citizens, patients, private parties, and experts from various disciplines (life sciences, health economics, humanities, social sciences, communication). To closely match the wishes and needs of citizens, the program will be developed and implemented with citizens, including vulnerable groups, and other stakeholders in 4 regions in the Netherlands (Breda, Utrecht, Arnhem, and Eindhoven). 160,000 people (50-75 years) will be invited for a home-based test using the Check@Home digital platform. In case of early signs of type 2 diabetes, cardiovascular or kidney damage, a targeted work-up will follow in a regional diagnostic center. If necessary, lifestyle advice and initiation of medication will be provided to relieve regular care as much as possible.