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FAIR share: ex vivo conservation of Zebrafish models

Funder: Netherlands Organisation for Scientific Research (NWO)Project code: VidW.1154.18.046

FAIR share: ex vivo conservation of Zebrafish models

Description

The significance of zebrafish for biomedical research is rapidly increasing globally . As a vertebrate species, they can model for the phenotypic outcome of genetic alteration and in many cases provide a model for human disease. The research of the applicant focuses on myopia that is spreading epidemically in the human population, and other collaborating groups focus on cognition disorders. The great success of biomedical modelling in fish is also a pitfall as it is quite impossible to maintain lines for longer periods of time by breeding. Also, catalogues of collections will never be accurate unless the material is available in a sustainable way. The zebrafish research community is commonly exchanging materials but only sustainable archives (cryopreserved) can adequately cater for cataloguing and exchange according to FAIR data stewardship. Also, models need to remain available to verify scientific outcomes, as there is a general concern about the reproducibility of research outcomes, and characterized models need to investigated and applied wider. To advance zebrafish archiving technology will be of immediate and long term benefit of life sciences research, both biomedical and fundamental. The candidate is an expert in animal reproductive technology.

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