Shaping the genome at macro-scale
Nederlands Kanker Instituut, Antoni van Leeuwenhoek Ziekenhuis, Gene Regulation B4 , Nederlands Kanker Instituut, Antoni van Leeuwenhoek Ziekenhuis, Celbiologie , Nederlands Kanker Instituut, Antoni van Leeuwenhoek Ziekenhuis, Celbiologie I , Nederlands Kanker Instituut , Nederlands Kanker Instituut
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Nederlands Kanker Instituut, Antoni van Leeuwenhoek Ziekenhuis, Gene Regulation B4 , Nederlands Kanker Instituut, Antoni van Leeuwenhoek Ziekenhuis, Celbiologie , Nederlands Kanker Instituut, Antoni van Leeuwenhoek Ziekenhuis, Celbiologie I , Nederlands Kanker Instituut , Nederlands Kanker Instituut
A cell is often likened to a bowl of spaghetti, in which each chromosome reflects a single entity of pasta. Remarkably though, the different chromosomes are not intermingled, as each chromosome is confined to its own region. What actually keeps the chromosomes apart? And what purpose does this serve? Molecular machines known as condensin play a central role in these processes. We have discovered how cells activate condensin such that it can correct structure our chromosomes.
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