This research focuses on implementing sit-to-stand desks in higher education to reduce sedentary time and improve student mental wellbeing. Since students in higher vocational education and academic education have less classes and more self-study hours than students in vocational education and training (VET), previous findings from VET cannot be directly translated to higher education. Through co-creation, we explore the needs and preferences of higher education students to implement sit-to-stand desks. Subsequently, we test the effect of this implementation during six months on physical activity, mental wellbeing, and academic performance. Positive results can stimulate wider use of sit-stand desks in education.