Uncovering dopamine signaling in the insular cortex
Radboud Universiteit Nijmegen , Oregon Health & Science University, Vollum Institute , Universiteit Utrecht , Oregon Health & Science University , Universiteit Utrecht, Faculteit Bètawetenschappen, Departement Biologie , Radboud Universiteit Nijmegen, Donders Institute - Donders Institute for Brain, Cognition and Behaviour
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Radboud Universiteit Nijmegen , Oregon Health & Science University, Vollum Institute , Universiteit Utrecht , Oregon Health & Science University , Universiteit Utrecht, Faculteit Bètawetenschappen, Departement Biologie , Radboud Universiteit Nijmegen, Donders Institute - Donders Institute for Brain, Cognition and Behaviour
The release of dopamine in our insula, a brain area, is important for the regulation of drug addiction. However, little is known about how dopamine regulates the insular neural network activity. This research has identified insular cortical neuron types, each with characteristic morphological, functional, and connective properties. The release of dopamine triggers changes in the functional properties of only a subset of the identified neuron types. This project highlights potential candidate neuron types to further investigate/manipulate during behaviors related to drug addiction.
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