Adapting phages to overcome bacterial defense barriers
Universitair Medisch Centrum Utrecht, Medische Microbiologie , Universitair Medisch Centrum Utrecht , Technische Universiteit Delft, Faculteit Technische Natuurwetenschappen, Chemical Engineering, Applied Sciences , Universitair Medisch Centrum Utrecht , Universiteit Utrecht, Faculteit Bètawetenschappen, Departement Biologie, Microbiologie , Technische Universiteit Delft , Universiteit Utrecht , Technische Universiteit Delft, Applied Science, RST/Biomedical Imaging
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Universitair Medisch Centrum Utrecht, Medische Microbiologie , Universitair Medisch Centrum Utrecht , Technische Universiteit Delft, Faculteit Technische Natuurwetenschappen, Chemical Engineering, Applied Sciences , Universitair Medisch Centrum Utrecht , Universiteit Utrecht, Faculteit Bètawetenschappen, Departement Biologie, Microbiologie , Technische Universiteit Delft , Universiteit Utrecht , Technische Universiteit Delft, Applied Science, RST/Biomedical Imaging
Bacteriophages are viruses that can kill bacteria and are a promising alternative for the treatment of antibiotic resistant bacterial infections. Recently we discovered that bacteria have accumulated defense mechanisms to avoid phage killing. Fortunately phages have developed counter defense mechanisms. In this project we want to combine these counter defense mechanisms and create a phage that is able to infect a broader range of bacteria with different defense mechanisms. Broadening the activity of bacteriophages is an important step in the clinical application of phage therapy
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