From the earliest invention of the camera, humans have been seeking to observe processes that are too fast or too complex for the human eye to follow. The first time-lapse images of a running horse, taken by Eadweard Muybridge in the 19th century, allowed us to understand its motion, freezing a moment in time so that we can examine minute details. It showed that a horse's feet all leave the ground when galloping, a controversial question hotly debated at the time. Importantly, the time lapse images were a full-frame view - a key concept which we will also employ in the instrument to be developed here. Today, in cellular biology, our understanding of cellular function continues to evolve as we observe complex dynamic processes played out under a microscope. The optical microscope is a non-invasive, non-destructive and non-ionising tool which can be used to study living cells and tissues. No other method can study molecules in living cells with anything remotely approaching its combination of spatial resolution, selectivity, sensitivity and dynamics. Modern sensitive and sophisticated electronic cameras can capture dynamic processes at high speed, revealing intricate details of these processes. Indeed, detector development is a very important aspect of progress in the field of microscopy. The aim of our project is to develop extremely sensitive and fast full-frame view cameras which will allow us to observe molecules and proteins in their natural habitat, the cell, without disturbing them - in a way the 21st century equivalent of Muybridge's galloping horse. We are interested in molecules that play a role in inflammation, which is the body's response to some kind of harm or injury. These molecules are called proteins, and they are many different ones in our cells. We specialise in finding out about a protein called the coxsackie virus adenovirus receptor (CAR). We want to know how they move around in time, bump into each other and stick together. So we have labelled them with a fluorescent label to observe them under a microscope. The special cameras we are going to develop will be able to see them with a very high resolution, and also very quickly and very precisely, by measuring the polarization of the fluorescence emitted by its label. They will allow us to observe the moment a cell responds to a chemical stimulus at the level of single proteins. This will help us to understand how inflammation occurs, on a molecular basis - which, at the moment, is still unknown. Imaging living cells is the best available approach to study this kind of biological question, and others, and, ultimately, the knowledge and insight gained by doing this work will enable us to design and develop drugs against inflammation, for the benefit of all of humankind.