Self-renewal in Leukaemia Stem Cells: identification of novel self-renewal pathways and the role of homeobox proteins
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Recent research in leukaemia and other cancers suggests that a critical subpopulation of cells within the cancer control the growth and spread of these tumours, the so called cancer stem cells A likely explanation for the lack of effect of many cancer therapies or the recurrence of tumours following therapy is that current drugs do not affect this important population of cells. Using leukaemia as a model for all cancers, this proposal aims to identify the mechanisms which control the renewal of these cancer stem cells and therefore the ability of the cancers to continue growing. This research should improve our understanding of the mechanisms of cancer growth and help to identify new therapies to target these critical cells and improve the treatment of cancer patients
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