DNA carries the genetic information of a cell and consists of thousands of genes that encode all the information required to make proteins. Genes (DNA) are copied into a molecule called RNA (pre-mRNA) in a process known as transcription. This pre-mRNA is then processed so that non-coding parts are removed and is then transported out of the nucleus to be ultimately translated into proteins in the cytoplasm. Our laboratory is interested in different aspects of how the pre-mRNA is accurately processed into mature mRNA, which then undergoes translation as part of the protein synthesis to produce proteins. Defects in RNA processing are linked to human disease. Our research program is at the basic end of the spectrum and we expect to contribute to the general knowledge in the areas of RNA processing and nuclear structure that could be applicable to human genetics.