This project aims at investigating the chemistry of a-aminoendoperoxides. This class of reactive molecules has a great potential for the development of powerful and original methods in organic synthesis, and for applications to the synthesis of complex nitrogen-containing polycyclic systems. Their reactivity has been scarcely studied so far and remains essentially unexplored. The foundations of our proposition lie on the scientific expertise of the three partners, whose know-how will be engaged in a synergic fashion. Beyond the synthesis of aminocyclopropanes by the Kulinkovich-de Meijere reaction, that we know well, and the electrochemical oxidation method that we have recently developed, we will focus a great deal of our efforts to new, particularly ambitious aspects of this chemistry: the improvement and the extension of the Kulinkovich-de Meijere reaction using the advantages of electrochemistry, the generalisation of the controlled oxidation of cyclopropylamines to other types of cyclopropanes with a low ionisation potential, or the development of alternative methods relying on photocatalytic processes, even more liable to fulfil the requirements of the current global context targeted towards sustainable development. We will synthesise a range of novel natural product-like or drug-like molecules. Their biological activities will be systematically scrutinised.